abstract：PURPOSE:Molecular mechanisms of response to hypomethylating agents in patients with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) still remain largely unknown. Therefore, the effects of 5-Azacytidine (Aza) on clonal architecture and DNA methylation were investigated in this study. METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Gawlitza AL,Speith J,Rinke J,Sajzew R,Müller EK,Schäfer V,Hochhaus A,Ernst T

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:Papillary thyroid carcinoma (PTC), the most common malignant tumor of the thyroid, has been criticized as overtreated by some researchers in recent years. Active surveillance (AS) was first proposed at Kuma Hospital in 1993, and popularized in other institutes ever since. We provide a brief review of low-risk P...

journal_title：Journal of cancer research and clinical oncology

authors： Ze Y,Zhang X,Shao F,Zhu L,Shen S,Zhu D,Bi Y

更新日期：2019-11-01 00:00:00

abstract：:In the original publication, the 6th author's first name and the last name was inverted and incorrectly published. The correct author name is Letizia Ferella. ...

journal_title：Journal of cancer research and clinical oncology

authors： Marampon F,Leoni F,Mancini A,Pietrantoni I,Codenotti S,Ferella L,Megiorni F,Porro G,Galbiati E,Pozzi P,Mascagni P,Budillon A,Maggio R,Tombolini V,Fanzani A,Gravina GL,Festuccia C

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Since 1997, several monoclonal antibodies (mAbs) targeting the same receptor or its ligand have been approved for use in oncology. However, no studies have summarized head-to-head trials of these mAbs. METHODS:Systematic search of the biomedical literature and ClinicalTrials.gov for randomized studies compa...

journal_title：Journal of cancer research and clinical oncology

authors： Luo J,Nishikawa G,Prasad V

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:Based on the poor prognosis of drug resistance in pediatric acute lymphoblastic leukemia (ALL) and adverse effects of chemotherapy, this study was aimed to evaluate the effect of several herbal extracts on leukemic cells. METHODS:Two subtypes of T- and B-ALL cell lines, followed by ALL primary cells were treat...

journal_title：Journal of cancer research and clinical oncology

authors： Rahimi Babasheikhali S,Rahgozar S,Mohammadi M

更新日期：2019-08-01 00:00:00

abstract：CONTEXT:Parathyroid carcinoma (PC) is a rare endocrine malignancy with no approved systemic therapies for unresectable locally invasive or distant metastatic disease. Understanding the molecular changes in advanced PC can provide better understanding of this disease and potentially help directing targeted therapy. OBJ...

journal_title：Journal of cancer research and clinical oncology

authors： Kutahyalioglu M,Nguyen HT,Kwatampora L,Clarke C,Silva A,Ibrahim E,Waguespack SG,Cabanillas ME,Jimenez C,Hu MI,Sherman SI,Kopetz S,Broaddus R,Dadu R,Wanland K,Williams M,Zafereo M,Perrier N,Busaidy NL

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Triple negative breast cancer (TNBC) harbors a heterogeneous group of carcinomas with poor prognosis and high genetic variability. As a potential aim for targeted therapy, genetic mutations leading to an activation of the phosphoinositide 3-kinase pathway in a catalytic subunit (PIK3CA) in breast cancer have...

journal_title：Journal of cancer research and clinical oncology

authors： Elfgen C,Reeve K,Moskovszky L,Güth U,Bjelic-Radisic V,Fleisch M,Tausch C,Varga Z

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:The growth pattern of peripheral squamous cell carcinoma (SCC) of the lung is divided into two types: alveolar space-filling (ASF) growth and alveolar space-destructive (ASD) growth. The aim of this study was to investigate the clinicopathological differences between cancer cells displaying ASF and ASD growth. ...

journal_title：Journal of cancer research and clinical oncology

authors： Omori T,Aokage K,Nakamura H,Katsumata S,Miyoshi T,Sugano M,Kojima M,Fujii S,Kuwata T,Ochiai A,Ikeda N,Tsuboi M,Ishii G

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:In the United States, cancer is the second leading cause of mortality, and millions more battle cancer worldwide. As such, primary prevention of cancer is a major interest globally. Aspirin has been studied as a primary prevention method for multiple diseases, mainly cardiovascular disease and various forms ...

journal_title：Journal of cancer research and clinical oncology

authors： Haykal T,Barbarawi M,Zayed Y,Yelangi A,Dhillon H,Goranta S,Kheiri B,Chahine A,Samji V,Kerbage J,Katato K,Bachuwa G

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To study an association between IL-6 signaling and resistance to radiotherapy of prostate cancer (PCa) and explore the molecular mechanisms involved. METHODS:IL-6 expressing C4-2 and CWR22Rv1 (C4-2IL-6/CWRIL-6) and vector control (C4-2vec/CWRvec) cell lines were developed. Radiation-sensitivities of these cell...

journal_title：Journal of cancer research and clinical oncology

authors： Chen X,Chen F,Ren Y,Weng G,Xu L,Xue X,Keng PC,Lee SO,Chen Y

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:In the phase 3 BFORE trial (NCT02130557), treatment with bosutinib resulted in a significantly higher major molecular response rate at 12 months versus imatinib in the modified intent-to-treat (mITT) population of patients with newly diagnosed chronic phase chronic myeloid leukemia (CP CML). Assessment of pa...

journal_title：Journal of cancer research and clinical oncology

authors： Cortes JE,Gambacorti-Passerini C,Deininger MW,Mauro MJ,Chuah C,Kim DW,Milojkovic D,le Coutre P,Garcia-Gutierrez V,Crescenzo R,Mamolo C,Reisman A,Hochhaus A,Brümmendorf TH,BFORE Study Investigators.

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Constructed from a theoretical framework, the coordinated undermining of survival paths in glioblastoma (GBM) is a combination of nine drugs approved for non-oncological indications (CUSP9; aprepitant, auranofin, captopril, celecoxib, disulfiram, itraconazole, minocycline, quetiapine, and sertraline) combined w...

journal_title：Journal of cancer research and clinical oncology

authors： Skaga E,Skaga IØ,Grieg Z,Sandberg CJ,Langmoen IA,Vik-Mo EO

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Maintaining telomeres by recruiting telomerase-to-chromosome ends is essential for cancer cell survival. Inhibiting telomerase recruitment to telomeres represents a novel strategy for telomere-based lung cancer therapy. However, approaches for interrupting telomerase recruitment for cancer therapy still need to...

journal_title：Journal of cancer research and clinical oncology

authors： Zhu J,Liu W,Chen C,Zhang H,Yue D,Li C,Zhang L,Gao L,Huo Y,Liu C,Giaccone G,Zhang B,Wang C

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Adenovirus (Ads) is one of the most popular vectors used in gene therapy for the treatment of cancer. However, systemic therapy is limited by circulating antiviral antibodies and poor viral delivery in vivo. In this study, we used cytokine-induced killer (CIK) cells as delivery vehicles of Ads KGHV500 carrying ...

journal_title：Journal of cancer research and clinical oncology

authors： Lin XR,Zhou XL,Feng Q,Pan XY,Song SL,Fang H,Lei J,Yang JL

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Aberrant expression of RNA-binding motif protein 3 (RBM3) has been suggested as a prognostic biomarker in several malignancies. MATERIALS AND METHODS:This study was performed to analyse the prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers (NSCLCs). Therefore, we t...

journal_title：Journal of cancer research and clinical oncology

authors： Melling N,Bachmann K,Hofmann B,El Gammal AT,Reeh M,Mann O,Moebius C,Blessmann M,Izbicki JR,Grupp K

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Cancer is a serious public health problem worldwide, and difficulty in early diagnosis has been the chief obstacle to improve the prognosis of patients. Recently, microRNAs (miRNAs) were widely studied to be potential biomarkers for cancer detection. miR-16 is a prevalent but sophisticated one. In the curren...

journal_title：Journal of cancer research and clinical oncology

authors： Huang Z,Chen W,Du Y,Guo Q,Mao Y,Zhou X,Hua D

更新日期：2019-03-01 00:00:00

abstract：:Tumour angiogenesis is defined by an anarchic vasculature and irregularities in alignment of endothelial cells. These structural abnormalities could explain the variability in distribution of nanomedicines in various tumour models. Then, the main goal of this study was to compare and to characterize the tumour vascula...

journal_title：Journal of cancer research and clinical oncology

authors： Pautu V,Mellinger A,Resnier P,Lepeltier E,Martin L,Boussemart L,Letournel F,Passirani C,Clere N

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Renal cell carcinoma (RCC) is the most common malignancy of the urinary system, and it is a serious threat to human health. HOXA transcript at the distal tip (HOTTIP), located at the 5' end of the HOXA locus, is a long non-coding RNA that has been newly discovered in recent years. It has been reported to prom...

journal_title：Journal of cancer research and clinical oncology

authors： Su Y,Lu J,Chen X,Liang C,Luo P,Qin C,Zhang J

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:In certain cancer settings, a T-cell response to cancer represents a relatively favorable outcome. Thus, the near-future challenges include a better understanding of exactly which T-cell features contribute to a response to which cancer antigen-groups, to maximize the opportunities for tumor-infiltrating lympho...

journal_title：Journal of cancer research and clinical oncology

authors： Chobrutskiy BI,Zaman S,Diviney A,Mihyu MM,Blanck G

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:Mutations in the tumor suppressor gene TP53 are associated with a variety of cancers. Therefore, it is important to know the occurrence and prognostic effects of TP53 mutations in certain cancers. METHODS:Over 29,000 cases from the April 2016 release of the International Agency for Research on Cancer (IARC) TP...

journal_title：Journal of cancer research and clinical oncology

authors： Li VD,Li KH,Li JT

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:Tumor grade is one of the more controversial factors with limited prognostic information in squamous cell carcinomas (SCC) of the uterine cervix. METHODS:Histologic slides of 233 surgically treated cervical SCC (FIGO IB1) were re-examined regarding the prognostic impact of the WHO-based grading system, using t...

journal_title：Journal of cancer research and clinical oncology

authors： Horn LC,Höhn AK,Hentschel B,Fischer U,Bilek K,Brambs CE

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:The introduction of immunochemotherapy has led to a significant improvement in treatment results and prognosis of diffuse large B-cell non-Hodgkins lymphoma (DLBCL) both at initial diagnosis and in relapse. Trofosfamide, an oxazaphosphorine derivative, has been utilized as alternative treatment option for patie...

journal_title：Journal of cancer research and clinical oncology

authors： Witte HM,Riecke A,Mayer T,Bartscht T,Rades D,Lehnert H,Merz H,Fetscher S,Biersack H,Gebauer N

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:PARP inhibitors (PARPi) are used in a wide range of human solid tumours but a limited evidence is reported in rhabdomyosarcoma (RMS), the most frequent childhood soft-tissue sarcoma. The cellular and molecular effects of Olaparib, a specific PARP1/2 inhibitor, and AZD2461, a newly synthesized PARP1/2/3 inhibito...

journal_title：Journal of cancer research and clinical oncology

authors： Camero S,Ceccarelli S,De Felice F,Marampon F,Mannarino O,Camicia L,Vescarelli E,Pontecorvi P,Pizer B,Shukla R,Schiavetti A,Mollace MG,Pizzuti A,Tombolini V,Marchese C,Megiorni F,Dominici C

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors' biology and explore t...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang F,Cai Z,Lv H,Li W,Liang M,Wei X,Zhou F

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:The fecal volatolome, which is composed of fecal volatile organic compounds (VOCs), seems to hold potential as non-invasive biomarker for the detection of colorectal cancer (CRC) and its precursor lesions advanced adenomas (AA). The potential of the fecal volatolome has been subject of various studies usin...

journal_title：Journal of cancer research and clinical oncology

authors： Bosch S,Berkhout DJ,Ben Larbi I,de Meij TG,de Boer NK

更新日期：2019-01-01 00:00:00

abstract：:Ovarian cancer is a leading cause of death among gynecologic malignancies. This disappointing prognosis is closely related to intrinsic or acquired resistance to conventional platinum-based chemotherapy, which can affect a third of patients. As such, investigating relevant molecular targets is crucial in the fight aga...

journal_title：Journal of cancer research and clinical oncology

authors： Gasparri ML,Besharat ZM,Farooqi AA,Khalid S,Taghavi K,Besharat RA,Sabato C,Papadia A,Panici PB,Mueller MD,Ferretti E

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Hypersensitivity reactions (HSRs) to chemotherapy is an ongoing issue in cancer treatments. Strategies to induce tolerance and maximize chemotherapy efficacy include desensitization protocols. The precise impact of these protocols, however, in the long-term treatments remains unclear. We aim to compare overall ...

journal_title：Journal of cancer research and clinical oncology

authors： Altwerger G,Florsheim EB,Menderes G,Black J,Schwab C,Gressel GM,Nelson WK,Carusillo N,Passante T,Huang G,Litkouhi B,Azodi M,Silasi DA,Santin A,Schwartz PE,Ratner ES

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Early treatment of pancreatic ductal adenocarcinoma (PDAC) is significantly delayed due to the lack of liquid biopsy markers for early diagnosis at surgically resectable tumor stages. Recent studies suggest that microRNA-205 (miR-205) is involved in PDAC progression by post-transcriptional regulation of epithel...

journal_title：Journal of cancer research and clinical oncology

authors： Michael Traeger M,Rehkaemper J,Ullerich H,Steinestel K,Wardelmann E,Senninger N,Abdallah Dhayat S

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:We sought to characterize the clinical features and management of patients diagnosed as Kaposiform hemangioendothelioma (KHE) without cutaneous involvement. METHODS:The electronic patient chats at six Triple A hospitals in China were searched to find all patient diagnoses with KHE without cutaneous involvement...

journal_title：Journal of cancer research and clinical oncology

authors： Ji Y,Chen S,Li L,Yang K,Xia C,Li L,Yang G,Kong F,Lu G,Liu X

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Recently, we identified the microRNA-99 family as unfavorable prognostic factor in patients with pancreatic ductal adenocarcinoma (PDAC). The aim of this study is to evaluate its value as circulating biomarker for PDAC. METHODS:Tissue and corresponding preoperative blood samples of 181 patients with PDAC UICC ...

journal_title：Journal of cancer research and clinical oncology

authors： Stroese AJ,Ullerich H,Koehler G,Raetzel V,Senninger N,Dhayat SA

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:It is estimated that about half of cancer patients use at least one form of complementary and alternative medicines (CAM) in their life but there is a strong reticence of patients in talking about CAM with their oncologist. Primary aim of this study was to inform patients about CAM, focusing on their suppose...

journal_title：Journal of cancer research and clinical oncology

authors： Bozza C,Gerratana L,Basile D,Vitale MG,Bartoletti M,Agostinetto E,Russo S,Follador A,De Carlo E,Pella N,Sottile R,Fasola G,Puglisi F

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Tumor detection and visualization plays a key role in the clinical workflow of a patient with suspected cancer, both in the diagnosis and treatment. Several optical imaging techniques have been evaluated for guidance during oncological interventions. Optical coherence tomography (OCT) is a technique which ...

journal_title：Journal of cancer research and clinical oncology

authors： van Manen L,Dijkstra J,Boccara C,Benoit E,Vahrmeijer AL,Gora MJ,Mieog JSD

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:The study aim was to compare the disease control in two groups of patients affected by liver metastases from CRC treated with microwave ablation (MWA) or stereotactic body radiation therapy (SBRT). METHODS:We extracted data of patients treated between 2009 and 2016. Inclusion criteria were: (1) maximum diamete...

journal_title：Journal of cancer research and clinical oncology

authors： Franzese C,Comito T,Clerici E,Di Brina L,Tomatis S,Navarria P,Reggiori G,Viganò L,Poretti D,Pedicini V,Torzilli G,Solbiati L,Scorsetti M

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Castration-resistant prostate cancer (CRPC) refers to prostate cancer that has progressed after initial androgen deprivation therapy (ADT). Over the years, treatment strategies for metastatic CRPC (mCRPC) have undergone considerable changes. We performed a network meta-analysis to assess the effectiveness and t...

journal_title：Journal of cancer research and clinical oncology

authors： Wang Y,Zhang H,Shen W,He P,Zhou Z

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:The proto-oncogene forkhead box M1 (FOXM1) is associated with poor survival in many cancers. The impact of FOXM1 expression on progression-free survival (PFS) of non-muscle invasive bladder cancer (NMIBC) has not yet been investigated. The differential expression of FOXM1 between the different molecular NMIBC s...

journal_title：Journal of cancer research and clinical oncology

authors： Rinaldetti S,Wirtz R,Worst TS,Hartmann A,Breyer J,Dyrskjot L,Erben P

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Patients with metastatic nonseminomatous germ cell tumors (mNSGCT) and a high tumor burden or a poor performance status at initial diagnosis are at risk from potentially life-threatening early complications during or after the first chemotherapy cycle. The outcomes with dose-reduced first cycle of chemotherapy ...

journal_title：Journal of cancer research and clinical oncology

authors： Tryakin A,Fedyanin M,Bulanov A,Kashia S,Kurmukov I,Matveev V,Fainstein I,Gordeeva O,Zakharova T,Tjulandin S

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Gastric cancer (GC) is the second most common leading cause of cancer-related death. Cancer stem cell (CSC) with the mark of CD44 played an important role in GC. rMETase was wildly exploited as chemotherapeutic option for GC. Polymers synthetic nanoparticle drug delivery systems have been commonly used for c...

journal_title：Journal of cancer research and clinical oncology

authors： Li YF,Zhang HT,Xin L

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:Natural killer (NK) cells can kill transformed cells and represent anti-tumor activities for improving the immunotherapy of cancer. In previous works, we established human interleukin-15 (hIL-15) gene-modified NKL cells (NKL-IL15) and demonstrated their efficiency against human hepatocarcinoma cells (HCCs) in v...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang W,Zhang C,Tian Z,Zhang J

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:To evaluate the pattern of recurrence of breast cancer according to its biological subtype in a large cohort of patients treated with therapy representative of current practice. PATIENTS AND METHODS:Patients treated between 2000 and 2016 with known biological subtype were eligible. Data were prospectively coll...

journal_title：Journal of cancer research and clinical oncology

authors： Ignatov A,Eggemann H,Burger E,Ignatov T

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:Patterns of locoregional rectal cancer recurrences following total mesorectal excision (TME) were analyzed to define the irradiation volume, especially the lateral pelvic lymph node (LPLN). MATERIALS AND METHODS:Of 1243 patients who underwent TME without pelvic radiotherapy between 2005 and 2012, the data of 8...

journal_title：Journal of cancer research and clinical oncology

authors： Choi SH,Chang JS,Yoon HI,Jang DS,Kim NK,Lim JS,Min BS,Huh H,Shin SJ,Ahn JB,Koom WS

更新日期：2018-06-01 00:00:00